P-glycoprotein in the developing human blood–brain barrier
نویسندگان
چکیده
منابع مشابه
Pro-Inflammatory Cytokine Regulation of P-glycoprotein in the Developing Blood-Brain Barrier
Placental P-glycoprotein (P-gp) acts to protect the developing fetus from exogenous compounds. This protection declines with advancing gestation leaving the fetus and fetal brain vulnerable to these compounds and potential teratogens in maternal circulation. This vulnerability may be more pronounced in pregnancies complicated by infection, which is common during pregnancy. Pro-inflammatory cyto...
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The blood-brain barrier is composed of specialized endothelial cells that prevent various substances from entering the brain. P-glycoprotein is an important component of this barrier and is present in high concentration on the apical surface of these endothelial cells. It is an ATP-dependent transport protein thought to be involved in extruding a variety of structurally unrelated compounds and ...
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The blood-brain barrier is a major impediment to the entry of many therapeutic drugs into the brain. P-Glycoprotein is an ATP-dependent drug transport protein that is predominantly found in the apical membranes of a number of epithelial cell types in the body, including the blood luminal membrane of the brain capillary endothelial cells that make up the blood-brain barrier. Since P-glycoprotein...
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We attempted to assess regional differences in cerebral P-glycoprotein (P-gp) function by performing paired positron emission tomography (PET) scans with the P-gp substrate (R)-[(11)C]verapamil in five healthy subjects before and after i.v. infusion of tariquidar (2 mg/kg). Comparison of tariquidar-induced changes in distribution volumes (DVs) in 42 brain regions of interest (ROIs) failed to de...
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A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile plaques in the brain. Evidence is accumulating that decreased clearance of amyloid-β from the brain may lead to these elevated amyloid-β levels. One of the clearance pathways of amyloid-β is transport across the blood-brain barrier via efflux transporters. P-glycoprotein, an efflux pump highly expressed ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2016
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2016.5